Evaluation of the cytokine profile and vascular elasticity in middle-aged men with essential hypertension and combined pathology

The diagnosis and management of patients with polymorbid cardiovascular pathology is a significant challenge. pathogenesis many diseases, such as arterial hypertension, coronary heart disease, angina pectoris, well diabetes mellitus, obesity dyslipidemia are associated systemic inflammation. inflammatory process, both at the local levels, can make contribution to progression atherosclerosis endothelial dysfunction, provoke destabilization blood pressure. Therefore, it important develop new approaches identification chronic processes in body. It known that presence oral cavity inflammation increases risk disease. Periodontal pathology, leading an increased expression pro-inflammatory cytokines, affects initiation atherosclerosis, vasospasm, pressure dysregulation. be assumed against hypertension increase probability early vascular aging, overall risk, also chance other diseases cardiological profile research subject was determine elasticity parameters dynamics daily profile, level anti-inflammatory cytokines persons considering cavity. structure comorbidity number laboratory instrumental data middle-aged men combination periodontitis were analyzed comparison without healthy volunteers same age. A correlation shown between periodontal (diabetes dyslipidemia, anxiety depressive disorders, signs left ventricular hypertrophy by ECG, high ankle-brachial index marker peripheral atherosclerosis), variability pressure, altered cytokine predominance “vascular age” on ASCORE scale, stiffness, assessed 24-hour monitoring using “VasotensOffice” program.